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y or excess of them can be associated with osteoporosis. It has even been suggested that ! . • Dilated blood vessels – Typically histamine lowers blood pressure and dilates blood vessels which leads to low blood pressure and increased permeability. Even . and cause chest pain. • Nausea and motion sickness – Histamine can play a role in symptoms like vertigo, motion sickness, and nausea, and vitamin C supplementation may provide relief.Antihistamines have also been used to reduce post-operative nausea and vomiting. • Sleep disorders – First-generation antihistamines made us drowsy, revealing how histamine helps keep us alert. Normally, histamine H3 receptors reduce histamine activity so we can properly fall asleep or stay awake. which can contribute to chronic sleep disorders. • Hypothermia – Histamine released by the hypothalamus helps control body temperature which affects various body functions. Experiments on mice showed that histamine injected in the spinal cord can even produce hypothermia. (thiamine) levels in another study. • Diverticulitis – which generate massive inflammation. • Meniere’s disease – This condition involves chronic dizziness, tinnitus (ringing ears), and hearing loss which are associated with histamine levels. in a mixed manner by inhibiting histamine H3 receptors while enhancing H1 receptors. • Vulnerability to disease – Histamine increases the permeability of the blood-brain barrier whichcan leave us vulnerable to bacterial infections and other diseases. Disruptions of the blood-brain barrier play a role in the development of epilepsy, Alzheimer’s Disease, meningitis, and multiple sclerosis. Histamine on the horizon We can now begin to imagine how to change our diet, avoid certain drugs, and adjust our lifestyles to better regulate our histamine levels. By first identifying our allergens through thorough testing, we can reduce exposure and dramatically empty our “histamine bucket” and lower inflammation. Even if we have no allergies to avoid, we can improve our ability to breakdown non-allergic histamine with B and C vitamins. Ideally we can better prepare our bodies to handle histamine “spikes” as needed for fighting disease, increasing motivation, or simply tolerating delicious leftovers. We desperately need a way to identify and “scan” histamine content in our food and supplements prior to purchase and consumption. Packages can differ widely based on theirmicroscopic bacteria content – even within expiration dates. , but we need global standards for all foods and awareness of the risks surrounding fish, fermented foods, canned meats, alcohol, prepackaged meals, and other high-risk products. Similarly, daily tracking of our own histamine metabolism would help guide our diet and lifestyle. Recognizing the triggers can help us map our journey to good health and beyond! Update July 2013 – The Hidden Accomplices of Histamine Intolerance: Researchers are finding that including . Putrescine and cadaverine in foods can prevent the breakdown of histamine and contribute to symptoms of intolerance. Putrescine is highest in spoiled food, fruits and cheeses, while cadaverine can be high in aged meats, fish and cheese. Some migraine sufferers have noted sensitivity to with reduced levels of monoamine oxidase (MAO). Tyramine builds up in foods such as aged cheese, meats, fish, red wine, and soy sauce as well as high-protein foods that have beenstored over time. . Grapefruit juice, orange juice and cooked soybeans showed higher levels of putrescine, while lentil soup and cooked soybeans showed higher levels of spermidine and spermine. Mature cheddar cheese was high in all three polyamines, demonstrating how fermentation and storage can dramatically affect levels in many products. A wide range of spices can reduce polyamine activity, though . Yogurt and high fat milk showed lower levels of polyamines than other milk products, though more studies are necessary to find the relationship between fat, polyamines, and histamine burden on the body. Like histamine, biogenic amines can be produced by bacteria in food but cannot be broken down by cooking or freezing. Substances like (found in red grape skin) and can reduce histamine production and the allergic response, and interestingly these substances are also inhibiting tumor growth. .
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