The many faces of histamine intolerance
By Shari Cheves on December 17th, 2012
I am astounded at how many of us unknowingly suffer from excess histamine. Some of us itch or sneeze while others get headaches, migraines, joint pain, or nausea – within minutes or several hours after exposure! Our “histamine bucket” fills up based on factors such as genetics, allergies, medication, diet, environment, nutritional deficiencies, intestinal damage, and UV exposure. When our body cannot break down excess histamine, we suffer with and increased inflammation. When we realize what is really happening, we can better prevent and treat this misunderstood condition! Most of us know histamines through antihistamine drugs that relieve our suffering from allergies to pollen, insect bites, and even foods. Histamine is naturally produced in our body by mast cells or white blood cells, and it performs different functions by binding with histamine receptors. : Histamine H1 receptors: Smooth muscle and endothelial cells affecting skin; blood vessels (Benadryl and Claritin blockactivity of these receptors) Histamine H2 receptors: Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate (Histamine H2 receptor antagonist drugs have been used to reduce symptoms of dyspepsia and GERD) Histamine H3 receptors: Central nervous system controlling nerves, sleep, appetite and behavior Histamine H4 receptors: Thymus, small intestine, spleen, colon, bone marrow and white blood cells; Keep in mind, histamine is essential for us to properly function and fight off invading toxins. But when histamine accumulates faster than we can break it down, it triggers inflammation in dreaded patterns of histamine intolerance unique to each person and episode. Our battle with histamine can hide behind less obvious symptoms like headaches, foggy thinking, diarrhea, arrhythmia, sinus congestion, or itchy skin appearing within minutes or even several hours after exposure. Extreme histamine levels can trigger breathing difficulty and swelling calledanaphylaxis. The concept of histamine intolerance is rarely discussed by doctors but . So why haven’t we heard about this? Histamine intolerance is hugely underestimated in the population. Most people respond to symptoms of histamine intolerance with an aspirin, antacid, or other quick-fix pill that does not address the root problem. Sometimes histamine levels are raised due to allergy, but histamine intolerance is not a true allergy and it won’t show up on allergy tests. Unlike allergy testing, confirming a serious histamine intolerance isn’t easy or profitable for doctors. ” Each person has a unique set of symptoms that may not always recur in the same location or intensity. The only true test for histamine intolerance requires a strict histamine-free diet followed by a double-blind food challenge. With a true diagnosis, the standard treatment is even more dismal – a low-histamine diet for life. But don’t give up yet! What causes histamine levels to rise? Reduced or inhibitedenzymes: One of the more common reasons we suffer from histamine intolerance is the lack of enzymes diamine oxidase (DAO) and histamine-N-methyl transferase (HNMT). These enzymes break down histamine and keep it in check. DAO and HNMT levels may be genetically low in some individuals, blocked by drugs, or reduced from intestinal damage or diseases such as celiac. Though human research is lacking, . Though DAO testing has typically been limited to countries outside of the United States, shipped from a practitioner. Many factors affect the body’s histamine levels, and there are ways we can help reduce the load. Our exposure to allergens, diet, drug use, temperature, hormones, and nutritional deficiencies dramatically impact our histamine levels throughout the day. Imagine your histamine as a “bucket” that fills up and only reveals symptoms after overflowing. Allergies: Large amounts of histamine are promptly released when we are exposed to our allergens, and the most common allergensinclude mold, dust mites, animal dander, pollen, medications, insect stings, latex, and food. Interestingly, . It is important to avoid exposure to known or suspected allergies, especially when histamine levels are a potential problem. Get tested and avoid the triggers to start emptying the bucket! The most common food allergies include dairy, wheat, shellfish, eggs, and nuts. Contact allergies can include a wide range of substances such as rubber, nickel (in jewelry), acrylates (artificial nails), pine resin, and sunscreen or shampoo ingredients (such as benzophenone). Some people experience an early response to allergens, while others might only notice a late-phase response that can appear up to 10 hours later. Symptoms of this delayed response can last up to 24 hours. If any type of food allergy is suspected, consult with an allergist and start carefully taking notes about diet and symptoms. can help you keep online records of your health. Blood tests for both immediate and delayedfood allergies are available to doctors from , , and many others. Depending on the type of allergy exposure and related damage, a body may require days, weeks, or even months to fully recover. Air pollution and pollen: New research shows that air pollution contributes to cardiovascular disease by the increase in histamine and inflammation. . These collective studies suggest that both short- and long-term PM inhalation can enhance thrombotic and coagulation tendencies, potentially via increases in circulating histamine and inflammatory cytokines and/or activated white cells and platelets. – Interestingly, ! Future studies will undoubtedly reveal how particles in our environment can affect our immune system beyond the classic allergy response. Water pollution: in lab rats by increasing their sensitivity to allergens. Drug interference: , possibly increasing the risk of food poisoning and other symptoms of excessive histamine. , NSAIDs such as aspirin, ibuprofen and naproxen can causehistamine levels to rise. Opoid drugs and analgesics are the most common drugs used in hospitals, releasing histamine that results in uncomfortable itching for many patients. Excessive histamine can also result from drugs including (but not limited to) acetylcysteine, acetylsalicylic acid, alcuronium, alprenolol, ambroxol, amiloride, aminophylline, amitriptyline, cefuroxime, cefotiam, chloroquine, cimetidine, clavulanic acid, cyclophosphamide, D-tubocurarine, dihydralazine, dobutamine, isoniazid, metamizole, morphine, pancuronium, pethidine, prilocaine, propafenone, metoclopramide, pentamidin, thiopental, and verapamil. Foods high in histamine: Symptoms can often be prevented by avoiding foods high in histamine: Fermented foods like wine, aged cheese, aged or smoked meats, fermented soy products (including tofu and soy sauce), vinegar (including pickles, ketchup and prepared mustard), and sauerkraut Foods exposed to high amounts of bacteria such as fish/shellfish Leftover meats canquickly accumulate microorganisms which result in histamine formation Chocolate/cocoa, spinach, eggplant, nuts, pumpkin, tomato, strawberries, citrus fruits, and seasonings like cinnamon, chili powder, and cloves can stimulate the release of histamine Wheat-based products Beverages such as tea (herbal or regular) and soy milk are high in histamine Any type of alcohol interferes with the body’s ability to break down histamine. Prepackaged meals . Foods high in histadine (over 1000 mg) may also be problematic, as histadine converts to histamine: Game meat including buffalo, elk, moose, caribou Pork including loin, chops or other cuts, ham, bacon Soy protein Chicken and turkey Veal and beef, pastrami Lamb Fish including tuna, pike, cod, sunfish, perch, grouper, and others Cottage cheese Foods high in fat: and contre Supplement That Can Have An Effect On So Many Systems At Once.” -Dr. Ron Shuler, D.D.S., CCN, LN
“We Showed That Fucoidan, Extracted From Dietary Seaweed, Could Inhibit The Growth Of Harmful Cells.” – Maruyama, H., 2003 –
“Fucoidans Are Highly Effective Antiviral AgentsAnd They Inhibit Harmful Cell Movement Into Tissues.” – J. Helen Fitton, Ph.D. In Alternative Complimentary Therapies –
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For example, a study in European Journal of Clinical Nutrition found that a deficiency in various nutrients altered immunity, even when deficiency is relatively mild. Low levels of zinc, selenium, iron, copper, Vitamins A, C, E and B6 and folic acid dramatically weaken immunity and can possibly be linked to diabetes.
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1. Rejuvenates and restores cells 2. Powerful natural anti-inflammatory 3. Fortifies your immune system 4. Neutralizes free radicals 5. Purifies your blood and prevents clotting 6. Naturally increases your energy 7. Lowers your cholesterol… keeps LDL cholesterol low and healthy 8. Supports healthy blood flow 9. Combats high blood sugar 10. Helps the body fight viruses, bacteria, fungus and parasites 11. Promotes proper thyroid function 12. Enhances moisture retention of skin (keeps it younger looking) 13. Boosts liver function 14. Improves bone and joint health 15. Improves intestinal environment 16. Strengthens mucosal lining of digestive and urinary tracts 17. Fights obesity and abdominal fat 18. Combats metabolic syndrome 19. Pribute to chronic inflammation. Nutritional imbalances: When the body is low in B vitamins, vitamin C, and copper, histamine may not break down sufficiently to overcome symptomsof intolerance. Foods high in Bs include potatoes, sunflower seeds, and soybeans. Foods high in vitamin C include bell peppers, broccoli, brussels sprouts, kiwifruit, cantaloupe, and kale. Researchers found that vitamin C may work . Copper is required to form the DAO enzyme and in animals. . Foods high in copper include fresh basil, cocoa powder, cashews, soybeans (mature), herbal tea, sesame seeds, sunflower seeds, garbanzo beans, and lentils. Some foods like potato are also high in oxalate which can release histamine in certain people. Keep in mind that while citrus is high in vitamin C, it releases histamine within the body and can aggravate symptoms. A food allergy to any of the above foods will also increase histamine. Heat and UVB light: . Some people notice that rashes and skin conditions can worsen with exposure to sun and heat. Exercise: Some episodes of anaphylaxis have been . These extreme reactions are typically related to food allergens that were consumed prior tophysical activity. Strict avoidance of allergens may help prevent symptoms of histamine intolerance that occur during exercise – . . Hormones – including stress hormones: Rising estrogen levels have been associated with elevated histamine, and women might notice increased sensitivity and symptoms of histamine intolerance at different times in their monthly cycle. . Conversely, histamine appears to stimulate estrogen levels as well and exacerbate symptoms. , theoretically reducing the risk of excess histamine during that phase. . Reducing stress that activate mast cells which release histamine and other factors of inflammation. How can we manage a histamine overload? At times we can reach a “point of no return” where our histamine levels start the cascade of inflammation and aggravating symptoms. Nausea, diarrhea, skin rashes, headaches, and mental distress are common ways our body expresses inflammation from excess histamine, though each person experiences this differently. Seekimmediate medical attention for any signs of anaphylaxis! • Avoid further triggers in diet and environment. Don’t take risks until seeking medical advice and getting tested for true allergies. • Add a cold blast or slow warm-up. Ice packs can relieve affected skin and reduce histamine. Interestingly, . – applied for 25 minutes – with benefits increasing in subsequent tests. Make it very cold and quick, because a • Cortisone cream and colloidal silver are quick, simple remedies for skin reactions. Topical hydrocortisone cream relieves itching and may consequently help prevent infection. Avoid complex medications or herbal remedies that expose the skin to more allergens and harsh chemicals. Colloidal silver spray is a natural antibacterial remedy that helps prevent infection. • Oral antihistamines do not reduce histamine, but they block histamine receptors tohelp us sleep, heal, and fight inflammation. First-generation antihistamines make us drowsy with occasional side effects ofinsomnia and confusion. Second-generation, newer antihistamines do not make us drowsy but may cause headache and dry mucous membranes. Long-term use of oral antihistamines is associated with weight gain, and oral antihistamines do not improve DAO enzyme activity. • Corticosteroids are used locally as in the case of nasal sprays or systemically in pill form. While corticosteroids may provide immediate relief for some allergy symptoms, their . • as a powder from capsules can be applied to itchy skin to quickly reduce inflammation and histamine and relieve symptoms. This supplement can stain clothing so cover with a bandage or gauze. Individuals with asthma or an allergy to pollen or bee stings should avoid bee propolis. • reduces allergic and inflammatory activity in vitro. Interestingly, . • Probiotics show promising signs for alleviating allergic disease, and we are beginning to learn how these “good” bacterial strains can benefit the body in different ways. . . In this manner, thatcharacterizes excessive histamine activity in allergy, asthma, and autoimmune diseases. In fact, taking that can trigger excessive histamine. • Flavonoids – . These antioxidant compounds are found in kale, broccoli, capers, buckwheat, onions, apples, and asparagus. found in . • Enzymes – breaks down histamine internally, and routine intake of a food supplement like and can help prevent episodes in the long-term. What other behaviors and health conditions are related to histamine? • Food poisoning symptoms – Many outbreaks of food poisoning are actually caused by excessive histamine consumption in certain high-histamine foods. Scrombroid food poisoning results from eating spoiled fish containing toxic levels of histamine – not bacteria. Histamine poisoning resembles a food allergy and is often misdiagnosed. • Migraines – , including the . Yet typical antihistamine drugs that target histamine H1 and H2 receptors have not been effective for migraine. Future studies may targethistamine H3 or H4 receptors with better results. • Atopic dermatitis – This . • Motivation, appetite, and addiction – . In women this behavior may be enhanced by hormones, as histamine rises with elevated estrogen and luteinizing hormone throughout the monthly cycle. Indeed, . . Histamine feedback loops may also contribute to the success of very-low-calorie diets. In fact, . . ! Too much of a good thing? Excessive histamine in the brain is linked to addiction and in preliminary studies. Interestingly, . • Cancer – Although we may suffer from an excess of histamine and consequential inflammation, . Research shows that in different ways. Certain cancer cells produce a form of histamine (histidine decarboxylase) that represses inflammatory cell activity. at different stages! In fact, and inhibited by a topical drug that blocks histamine called H2 antagonist. This type of drug has been used to treat acid reflux, ulcers, and indigestion. Furthermore, histamine is being considered toprevent the damaging effects of cancer radiation therapy. “…histamine significantly protects two of the most radiosensitive tissues, small intestine and bone marrow, from high doses of radiation. In addition, histamine has the ability to prevent functional and histological alterations of salivary glands exerted by ionizing radiation.” – • Parkinson’s Disease and brain degeneration – Accumulated histamine in the brain can cause damage to neurons through inflammation. and . Furthermore, . • Multiple Sclerosis – Recent studies revealed that . • Inflammation – Histamine and its receptors are constantly engaged in a vital balancing act, preventing excessive inflammation while promoting homeostasis and healing. A variety of inflammatory diseases involve histamine activity. Animal models indicate that mast cells, through the secretion of various vasoactive mediators, cytokines and proteinases, contribute to coronary plaque progression and destabilization, as well as to diet-induced obesityand diabetes. – , and topical H2 antagonist drug cimetidine dramatically improves conditions. Patients with inflammatory (rheumatoid) arthritis have pain relief from . . Yet histamine may also protect us by inhibiting AGE activity which contributes to chronic inflammatory diseases such as cancer, diabetes, heart disease, and brain degeneration. Researchers found that , proposing that stimulating H2 receptors might help prevent atherosclerosis. • Osteoporosis – Mast cells which release histamine appear important to bone health, and a deficiencevents infections 20. Reduces effects of aging 21. Relieves pain 22. Supports healthy upper respiratory mucous membranes 23. Balances glands and hormones 24. Enhances long term memory formation 25. Mobilizes stem cells to enable tissue and organ regeneration26. Corrects mineral deficiencies 27. Increases longevity and disease resistance
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PubMed.gov reports more than 1,000 independent, third party, unsolicited studies have been conducted on Fucoidan, reported in medical journals such as…
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