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Does Lipitor Raise Blood Sugar Levels

I remember growing up, my farmer grandparents would go to bed before 9 and wake before the sun. They had earned it, working hard all day, but also resting in the afternoon when the Florida heat was too much to tend to the fields and animals. They, like most farmers, had a great understanding of what their bodies needed: rest and sleep to maintain a hard physical lifestyle. Now we stay glued to electronic devices and computers all day, do very little physical work that isn’t outside of a gym, and we don’t slow down for restful afternoon times that reset our clocks. We do mental work all day then do more work when we get home and stay up late for entertainment like television or social media. Burning the midnight oil has become a standard American attitude. But where it’s led is to a public health epidemic of insufficient sleep.

According to the CDC…. Sleep is increasingly recognized as important to public health, with sleep insufficiency linked to motor vehicle crashes, industrial disasters, and medical and other occupational errors. Unintentionally falling asleep, nodding off while driving, and having difficulty performing daily tasks because of sleepiness all may contribute to these hazardous outcomes. Persons experiencing sleep insufficiency are also more likely to suffer from chronic diseases such as hypertension, diabetes, depression, and obesity, as well as from cancer, increased mortality, and reduced quality of life and productivity. Sleep insufficiency may be caused by broad scale societal factors such as round-the-clock access to technology and work schedules, but sleep disorders such as insomnia or obstructive sleep apnea also play an important role. An estimated 50-70 million US adults have sleep or wakefulness disorder. Notably, snoring is a major indicator of obstructive sleep apnea.

According to data from the National Health Interview Survey, nearly 30% of adults reported an average of less than 6 hours of sleep per day in 2005-2007. In 2009, only 31% of high school students reported getting at least 8 hours of sleep on an average school night.

FUNCTION OF SLEEP: Circadian rhythms are physical, mental, and behavioral changes that follow a roughly 24-hour cycle, responding primarily to light and darkness in an organism’s environment. They are found in most living things, including animals, plants, and many tiny microbes. This internal clock, which gradually becomes established during the first months of life, controls the daily ups and downs of biological patterns, including body temperature, blood pressure, and the release of hormones. Circadian rhythms are important in determining human sleep patterns and have been linked to sleep disorders like insomnia. They’ve also been associated with obesity, diabetes, depression, bipolar disorder, and seasonal affective disorder.

Light is the main cue influencing circadian rhythms, turning on or turning off genes that control an organism’s internal clocks.

SLEEP DYSFUNCTION: For people suffering from sleep dysfunction lifestyle can be a major contributor. For people with adrenal fatigue, their second wind usually kicks in around 11pm and creates a pattern of insomnia. If you’re waking between 1 and 3 am your liver may be lacking the glycogen reserves needed for conversion by the adrenals to keep the blood glucose levels high enough during the night. Blood sugar is normally low during the early morning hours but, if you are hypoadrenic your blood glucose levels may sometimes fall so low that hypoglycemic (low blood sugar) symptoms wake you during the night. This is often the case if you have panic or anxiety attacks, nightmares, or sleep fitfully between 1 and 4 am. Both too high and too low nighttime cortisol levels can cause sleep disturbances.

SLEEP AND STRESS: Our bodies are designed to handle acute stress. Being chased by a predator for example, we go into sympathetic mode otherwise known as fight or flight. Resources are prioritized and survival takes over which suppresses immune function, digestion, sex hormone production, for instance. To put into modern day terms, imagine when you’ve avoided a car accident. The stress hormones adrenaline, epinephrine, and dopamine take over. Your heart pounds, your hands my sweat, it takes you some time to calm down and recover. Our bodies can handle those types of situations when it’s a rare occasion. It becomes a problem when we live in a chronic sympathetic state like so many Americans do these days. Chronic stress looks like this:

Your circadian rhythms are easily disrupted if cortisol is continuously released due to chronic stress. If cortisol remains high at night, melatonin isn’t released. Even though you may be able to fall asleep despite high cortisol levels your rest may be disrupted causing further stressors that create a vicious cycle.

Problems from chronic stress causing sleep issues: Adrenal Fatigue Digestive, not eating in a parasympathetic mode causes digestion dysfunction Insulin resistance/weight management Inflammation Mood disorders

SLEEP HYGIENE: Maintain a regular bed and wake time schedule including weekends. It’s important to keep a regular bedtime and wake-time, even on the weekends when there is the temptation to sleep-in. A second wind hits at about 11pm which is why it is important to be in bed and on your way to sleep by 10:30 to prevent your adrenal glands from kicking into overdrive. Even if your night has been restless or sleep fitfull, sleeping between 7-9am can be restorative

Establish a regular, relaxing bedtime routine such as soaking in a hot bath or hot tub and then reading a book or listening to soothing music. Avoid arousing activities before bedtime like working, paying bills, engaging in competitive games or family problem-solving. Some studies suggest that soaking in hot water before retiring to bed can ease the transition into deeper sleep, but it should be done early enough that you are no longer sweating or over-heated. If you are unable to avoid tension and stress, it may be helpful to learn relaxation therapy from a trained professional. Finally, avoid exposure to bright before bedtime because it signals the neurons that help control the sleep-wake cycle that it is time to awaken, not to sleep.

Create a sleep-conducive environment that is dark, quiet, comfortable and cool. Design your sleep environment to establish the conditions you need for sleep – cool, quiet, dark, comfortable and free of interruptions. Also make your bedroom reflective of the value you place on sleep. Check your room for noise or other distractions, including a bed partner’s sleep disruptions such as snoring, light, and a dry or hot environment. Consider using blackout curtains, eye shades, ear plugs, “white noise,” humidifiers, fans and other devices.

Use your bedroom only for sleep and sex. It is best to take work materials, computers and televisions out of the sleeping environment. Use your bed only for sleep and sex to strengthen the association between bed and sleep. If you associate a particular activity or item with anxiety about sleeping, omit it from your bedtime routine. For example, if looking at a bedroom clock makes you anxious about how much time you have before you must get up, move the clock out of sight. Do not engage in activities that cause you anxiety and prevent you from sleeping.

Finish eating at least 2-3 hours before your regular bedtime. Eating or drinking too much may make you less comfortable when settling down for bed. It is best to avoid a heavy meal too close to bedtime. Also, spicy foods may cause heartburn, which leads to difficulty falling asleep and discomfort during the night. Try to restrict fluids close to bedtime to prevent nighttime awakenings to go to the bathroom, though some people find milk or herbal, non-caffeinated teas to be soothing and a helpful part of a bedtime routine.

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Recently somebody ask the following 2 great questions: Please tell me what the numbers are for normal BS levels in your country. In Canada we use a different scale and would like to compare the two. I am also curious to know about the antibody tests that seem to be standard practice down there and not in Canada. Blood Sugar Levels What constitutes normal blood sugars in not as cut and dry as it may seem. There are disagreements between the various institutions as to how to define normal blood glucose levels. Of course there are politics involved in determining some of these numbers. Factors such as age and genetics can also affect normal ranges. With that said, I think the chart below is one of the better charts for showing the range of blood glucose levels from normal to established diabetes. This chart is in the U.S. unit of measure, which is mg/dL, and the blood glucose values are for plasma blood glucose. There is an easy to use that helps you to get your blood sugar conversionresults either in mg/dL (U.S. system) or in mmol/L (European system). Glucose vs. Plasma Glucose Glucose levels in plasma (one of the components of blood) are generally 10%–15% higher than glucose measurements in whole blood (and even more after eating). Glucose is dissolved in water. The plasma phase of blood has a higher concentration of water (~93%) compared to that of red blood cells (~71%). Therefore plasma has a higher glucose concentration than that of whole blood. This is important to know because home blood glucose meters measure the glucose in whole blood while most lab tests measure the glucose in plasma (may also be called serum glucose). Currently, there are many meters on the market that give results as “plasma equivalent,” even though they are measuring whole blood glucose. The plasma equivalent is calculated from the whole blood glucose reading using an equation built into the glucose meter. This allows you easily to compare your glucose measurements in a lab test andat home. It is important for you (and your health care provider) to know whether your meter gives its results as “whole blood equivalent” or “plasma equivalent.” for a great resource that demonstrates how these two numbers map to each other by inputting your latest A1c. The next chart shows how the American Diabetes Association (ADA) determines a diagnosis for diabetes, and it contains both the U.S. unit of measure and the European unit of measure: You will notice they have a footnote that says A1c does not apply to diagnosis of type 1 diabetes. That is because type 1 diabetes is typically diagnosed in the hospital with high blood glucose levels that have come on quite rapidly. This makes using an A1c to diagnose it unnecessary, but it still may provide valuable information. Speaking of A1c, A hemoglobin A1C test is primarily used to measure average glucose over prolonged periods of time. The test measures the buildup of glycated hemoglobin (a type of advanced glycation end product, orAGE) within the red blood cells. This measurement reflects the average level of glucose the cell has been exposed during its life cycle which is approximately 10-12 weeks. There are many conversion tables available, and most of them do not agree. I know of at least three formulas for converting from an A1c to an average blood sugar level or vice versa.  The chart below is based on the conversion formula of Dr. Richard Bernstein. In my opinion this is the most accurate conversion correlation chart. According to Dr. Richard Bernstein a normal, healthy, thin, non-diabetic A1C will be within the range of 4.2-4.6. He also believes every diabetic can and should target, attain and sustain these normal levels. The American Diabetes Association (ADA) states an A1C of less than 6.0 is normal and recommends an A1C less than 7.0 in diabetics. The American College of Endocrinology (ACE) and the American Association of Clinical Endocrinologists (AACE) adopted a target A1C of less than 6.5 percent attheir diabetes treatment consensus conference in 2001. Although the diabetes experts disagree on the definition of a normal A1C and a target A1C for diabetics, they do agree that lowering A1C has been associated with a reduction in microvascular and neuropathic complications of diabetes and possibly macrovascular disease. The ADA states “More stringent goals (i.e., a normal A1C less than 6 percent) should be considered in individual patients based on epidemiological analyses suggesting that there is no lower limit of A1C at which further lowering does not reduce the risk of complications…(particularly in those with type 1 diabetes).” We believe targeting an A1c below 5.6 is best, because that is supposedly the threshold above which microvascular and macrovascular disease is most likely to occur. Antibody Tests Most people who develop type 1 diabetes have immune markers in their blood such as antibodies against insulin, islets, or the enzymes glutamic acid decarboxylase (GAD) and IA2(also known as ICA512). By measuring these markers and conducting metabolic tests, scientists can now gauge the risk for developing type 1 diabetes in relatives of people with the disease. Tests include: People who are treated with insulin injections may begin to develop antibodies directed against the exogenous insulin. The IAA test does not distinguish between these types of antibodies and the autoantibodies directed against endogenous insulin. Therefore, this test is not valid for someone who has already been treated with injections of insulin. For example, someone who was thought to be a type 2 diabetic and who was treated with insulin injections cannot then have this test done to determine if they are actually a type 1 diabetic. The autoantibodies seen in children are often different than those seen in adults. IAA is usually the first marker to appear in young children. As the disease evolves, this may disappear and ICA, GADA and IA-2A become more important. IA-2A is less commonlypositive at the onset of type 1 diabetes than either GADA or ICA. Whereas about 50% of children with new-onset type 1 diabetes will be IAA positive, IAA positivity is not common in adults. Not everyone with autoantibodies progress to diabetes type 1, but the risk increases with the number of antibody types, with three to four antibody types giving a risk of progressing to diabetes type 1 of 60%-100%. If ICA, GADA, and/or IA-2A are present in a person with symptoms of diabetes, the diagnosis of type 1 diabetes is confirmed. Likewise, if IAA is present in a child with diabetes who is not insulin-treated, type 1 diabetes is the cause. If no diabetes-related autoantibodies are present, then it is less likely that the diabetes is type 1. Some people who have type 1 diabetes will never develop detectable amounts of islet autoantibodies, but this is rare. The majority of people, 85% or more, with new-onset type 1 diabetes will have at least one islet autoantibody.

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