For example, a primary defect at the level of incretin secretion or action is diagnosed with an impaired oral glucose tolerance in face of a normal intraperitoneal glucose tolerance. An impaired intraperitoneal glucose tolerance will suggest impairments in either insulin secretion or insulin sensitivity (or both together). It is, therefore, often coupled with an insulin tolerance test. Whenever a defect in insulin secretion is suspected, B cell function can be further assessed in vivo by a (GSIS) test, a , or ex vivo in during static infusions or perifusions experiments .
A minimum of 10 mice per group should be sent to our facility, one week prior to the experiment.
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