Modern American society demonizes fat consumption and links it to obesity, diabetes, and cardiovascular disease. Unfortunately, this is a misconception and is not the reason why so many Americans are overweight with underlying systemic diseases in the making or already underway. The real problem is the overconsumption of sugar and carbohydrates (particularly processed ones) in conjunction with poor quality fat and protein in improper ratios.
In Paleolithic times (which encompass the majority of human existence and what shaped our current genome), humans consumed macronutrient ratios between 19-35% protein, 22-44% carbohydrate, and 28-58% fat with no trans fats. Today, these ratios have shifted to 15% protein, 52% carbohydrate, and 33% fat of which 2-3% are trans fats. This means we are consuming less protein, more carbohydrates, and eating on the lower end of the proportion of fats coupled with toxic trans fats. Furthermore, sugar consumption has dramatically increased from 10 lbs per person per year in 1821 compared to 199 lbs in 2005 (USDA statistics).
Excessive sugar and carbohydrate consumption coupled with a lower fat and protein intake can result in an unstable and rapid glucose metabolism that typically requires frequent replenishing and compensatory stimulants. Carbohydrate digestion creates a quicker blood glucose elevation (high glycemic load) compared to fats and proteins which slow down the digestive process resulting in a steadier blood glucose state. The problem with rapid and large blood glucose surges (hyperglycemia) is that they ultimately create a stress response in the body. As blood glucose levels surge from either too much sugar/carbohydrate consumption and/or not enough protein and fat paired with it to slow the processing, the body reacts by releasing excessive insulin. This pancreatic hormone works to facilitate blood glucose transfer into liver and muscle cells for energy production and conversion into glycogen thereby lowering blood glucose levels. Any excessive amount that is not needed by the liver andmuscle will then be converted into adipose tissue.
As a response to hyperglycemia, the body typically over reacts and shifts into a state of reactive hypoglycemia (too low blood sugar). Symptoms of hypoglycemia include fatigue, irritability, cravings for sweets, more carbohydrates, and stimulants in order to facilitate bringing blood glucose levels up again. The body then responds by releasing the hormones glucagon (from the pancreas), cortisol, norepinephrine, and epinephrine (from the adrenal glands) which all act to elevate blood glucose levels. Stimulant cravings (particularly caffeine) are present in this reactive hypoglycemic state as the body desires increased sympathetic nervous system activity to help elevate blood sugar levels. People will typically crave caffeine at times when their blood sugar is low such as in the morning or in the middle of the afternoon. Stimulants may also be desired in cases of adrenal dysregulation where the adrenal glands are not producing adequate amounts of cortisol, epinephrine, ornorepinephrine. The body’s response to a reactive hypoglycemic state will usually once again create a reactive hyperglycemic state and thus a vicious repetitive cycle is born characterized by a roller coaster blood glucose ride. Eventually, dysregulation may further occur where the cells are no longer sensitive to insulin either due to receptor downregulation and/or receptors being destroyed through glycation. Glycation occurs with elevated glucose levels which adhere to proteins (AGEs-associated glycation end-products) including tissue membranes, joints, neurons, and/or red blood cells thus creating inflammation and degeneration. When cells no longer can take in glucose, the body’s ability to produce energy is impaired. The excessive glucose is then converted into fat. Furthermore, insulin resistance impairs the body’s ability to break down adipose tissue. Therefore, obesity is even more encouraged.
Foods that are high in sugar also typically contain high amounts of the sugar fructose. Fructose is processed differently than glucose in that the liver has to completely metabolize it vs 20% in glucose processing creating stress on the liver. Furthermore, fructose does not trigger the release of the hormone ghrelin as glucose does which suppresses appetite. Therefore, one is more likely to overeat. Also, for every 120 calories of fructose, 40 of them end up being stored as fat. Finally, the free fatty acids created via fructose metabolism are eventually converted into very-low-density lipoproteins (VLDL) (harmful to the body) and triglycerides which promote more fat storage in the liver and muscle. This can also facilitate insulin resistance.
It is evident how weight gain and blood sugar dysregulation are associated with increased consumption of carbohydrates and sugar (particularly fructose), under consumption of fat and protein, and/or over consumption of food period (too much healthy fat and protein can also lead to weight gain). However, it is also important to realize that chronic stress can also contribute to obesity and endocrine dysregulation. The stress response involves the release of cortisol and epinephrine which, as just explained, results in increased blood glucose levels. Therefore, a stress stimulus by itself can also facilitate a roller coaster blood sugar ride, glycation, and eventually insulin resistance. Furthermore, increased activation of the stress response pathways can also impact the thyroid gland which is a primary regulator of metabolism. Hypothyroidism, which is becoming more common in today’s society, will contribute to weight gain as well. The unfortunate result from chronic stress can manifestin obesity, diabetes, and any variety of chronic systemic inflammatory disease process.
Based on this discussion thus far it is clear that one should attempt to limit their sugar and carbohydrate consumption while being mindful of adequate and nutritious fat and protein intake. The use of stimulants are also not recommended. Stress management and coping strategies with today’s societal, work, and family demands is also crucial. Everyone’s physiology and genealogy is different and therefore there is typically not a single formula that will work for all. However, below are some general food choice recommendations:
Caveats
References
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