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Side Effects To Consider Reported side effects of both alendronate and risedronate include an increased incidence of upper gastrointestinal distress, heartburn, indigestion, chest discomfort, and pain with swallowing, although risedronate may have a lower rate of these problems. Studies have shown that as many as 56 percent of patients do not take the drug as recommended. When combined with naproxen (a non-steroidal anti-inflammatory drug), Fosamax produced ulcers in 38 percent of volunteers and significant side effects in 69 percent. A newly recognized side effect being discovered by users is that they are experiencing chronic, often severe joint and bone pain, swelling of ankles and feet, muscles, cramping and stiffness and difficulty walking. Most of the reports had to do with Fosamax. According to a 2005 Adverse Events Report from the FDA, pain was often described as severe, extreme, disabling or incapacitating and that many patients were unable to walk, climb stairs, or perform
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